Research Article

Best and effective practices of wound care and healing among patients with Diabetes Mellitus

Jefferson Garcia Guerrero*

Published: 19 December, 2018 | Volume 2 - Issue 1 | Pages: 025-031

Aim: With the continuing trend in the incidence of diabetic ulcer, the current researches on wound care and healing will bring best and effective practices on wound care and healing among patients suffering from diabetes mellitus.

Methods: This study utilized a systematic review of literatures in light of wound care through Pub Med database with the key words “Diabetes Mellitus,” “wound practices,” “wound healing,” and “systematic review.” The searched literatures were of case reports, interventional studies, and review papers whose main texts were in English.

Results: There were 7,988 published articles yielded from the keywords used and 16 were included in this study. The practiced management and techniques in these literatures focused on comfortable and cost efficient means of wound care and healing with the involvement of group participation than individual plan of care.

Conclusions: There are meager evidences of feasible wound and healing options that needs further studies in resolving wound issues among patients with Diabetes Mellitus. This systematic review establishes the insufficiency of high level of evidence based studies on wound healing in DM patients and brings a track for continuity of rigid studies concerning this topic.

Read Full Article HTML DOI: 10.29328/journal.cjncp.1001009 Cite this Article Read Full Article PDF


Systematic review; Diabetes mellitus; Wound care and practices; Wound healing


  1. Armstrong D, Meyr A. Basic principles of wound healing. UpToDate. 2018; Ref.: https://goo.gl/crDvCb
  2. Moncrieff G, Van Onselen J, Young T. The role of emollients in maintaining skin integrity. Wounds UK, 2015; 1: 68-74. Ref.: https://goo.gl/pUFBri
  3. World Health Organization. Diabetes. 2018; Ref.: https://goo.gl/eq9jNm
  4. World Union of Wound Healing Societies, Florence Congress, Position Document. Management of Biofilm. Wounds International. 2016; Ref.: https://goo.gl/VSyyqi
  5. Villines Z. Diabetes and wound healing: What to know [Internet]. Medical News Today. MediLexicon International; 2018; Ref.: https://goo.gl/SELS4o
  6. Chang JW, Heo W, Choi MSS, Lee JH. The appropriate management algorithm for diabetic foot: A single-center retrospective study over 12 years. Medicine (Baltimore). 2018; 97: e11454. Ref.: https://goo.gl/osJzoE
  7. Chen CY, Wu RW, Hsu MC, Hsieh CJ, Chou MC. Adjunctive Hyperbaric Oxygen Therapy for Healing of Chronic Diabetic Foot Ulcers: A Randomized Controlled Trial. J Wound Ostomy Continence Nurs. 2017; 44: 536-545. Ref.: https://goo.gl/8PUJmL
  8. Crews RT, Candela J. Decreasing an offloading device’s size and offsetting itsimposed limb-length discrepancy lead to improved comfort and gait. Diabetes Care. 2018; 4: 1400-1405. Ref.: https://goo.gl/YuFbjt
  9. Driver VR, Reyzelman A, Kawalec J, French M. A prospective, randomized, blinded, controlled trial comparingtransdermal continuous oxygen delivery to moist wound therapy for the treatment of diabetic ulcers. Ostomy Wound Manage. 2017; 63: 12-28. Ref.: https://goo.gl/tjw8fA
  10. Eraydin S, Avsar G. The effect of foot exercises on wound healing in type 2 diabetic patients with a foot ulcer: A randomized control study. J Wound Ostomy Continence Nurs. 2018; 45: 123-130. Ref.: https://goo.gl/r3bcyA
  11. Health Quality Ontario. Hyperbaric oxygen therapy for the treatment of diabetic foot ulcers: a health technology assessment. Ont Health Technol Assess Ser. 2017; 17: 1-142. Ref.: https://goo.gl/BXWZqG
  12. Lopez-Delis A, Fleury Rosa SSR, de Souza PEN, Carneiro MLB, et al. Characterization of the cicatrization process in diabetic foot ulcers based on the production of reactive oxygen species. J. Diabetes Res. 2018: 4641364. Ref.: https://goo.gl/D4V5k9
  13. Mathur RK, Sahu K, Saraf S, Patheja P, Khan F. et al. Low-level laser therapy as an adjunct to conventional therapy in the treatment of diabetic foot ulcers. Lasers Med Sci. 2017; 32: 275-282. Ref.: https://goo.gl/uPn1N1
  14. Mohammadi MH, Molavi B, Mohammadi S, Nikbakht M, Mohammadi AM. et al. Evaluation of wound healing in diabetic foot ulcer using platelet-rich plasma gel: A single-arm clinical trial. Transfus Apher. 2017; 56: 160-164. Ref.: https://goo.gl/NMB514
  15. Park KH, Han SH, Hong JP, Han SK, Lee DH, et al. Topical epidermal growth factor spray for the treatment of chronic diabetic foot ulcers: A phase III multicenter, double-blind, randomized, placebo-controlled trial. Diabetes Res Clin Prac. 2018; 142: 335-344. Ref.: https://goo.gl/hfwypG
  16. Pougatsch DA, Rader A, Rogers LC. The use of a sea salt-based spray for diabetic foot ulcers: a novel concept. Wounds. 2017; 29: E5-E9. Ref.: https://goo.gl/s82eoY
  17. Santema KTB, Stoekenbroek RM, Koelemay MJW, Reekers JA, van Dortmont LMC, et al. Hyperbaric oxygen therapy in the treatment of ischemic lower-extremity ulcers in patients with diabetes: results of the DAMO2CLES Multicenter Randomized Clinical Trial. Diabetes Care. 2018; 41: 112-119. Ref.: https://goo.gl/BftBgA
  18. Smith-Strøm H, Igland J, Østbye T, Tell GS, Hausken MF, et al. The effect of telemedicine follow-up care on diabetes-related foot ulcers: a cluster-randomized controlled noninferiority trial. Diabetes Care. 2018; 41: 96-103. Ref.: https://goo.gl/FuPQMd
  19. Volpe P, Marcuccio D, Stilo G, Alberti A, Foti G, et al. Efficacy of cord platelet gel application for enhancing diabetic foot ulcer healing after lower limb revascularization. Semin Vasc Surg. 2017; 30: 106-112. Ref.: https://goo.gl/i6wUfX
  20. Zelen CM, Orgill DP, Serena TE, Galiano RD, Carter MJ, et al. Human Reticular Acellular Dermal Matrix in the Healing of Chronic Diabetic Foot Ulcerations that Failed Standard Conservative Treatment: A Retrospective Crossover Study. Wounds. 2017; 29: 39-45. Ref.: https://goo.gl/zvPQKE
  21. Zelen CM, Orgill DP, Serena T, Galiano R, Carter MJ, et al. A prospective, randomised, controlled, multicentre clinical trial examining healing rates, safety and cost to closure of an acellular reticular allogenic human dermis versus standard of care in the treatment of chronic diabetic foot ulcers. Int Wound J. 2017; 14: 307-315. Ref.: https://goo.gl/i9goKg
  22. Dutton M, Chiarella M, Curtis K. The role of the wound care nurse: an integrative review. Br J Community Nurs. 2014; Suppl: S39-40, S42-7. Ref.: https://goo.gl/aJifvx
  23. International Best Practice Guidelines: Wound Management in Diabetic Foot Ulcers. Wounds International, 2013; Ref.: https://goo.gl/faFXPm

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